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Sharma, Ashish Kumar
- Effect of Varying Poisson Ratio on Thermally Induced Vibrations of Non-homogeneous Rectangular Plate
Authors
1 Department of Mathematics, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, IN
2 Department of Mathematics, ManavBharti University, Solan (H.P.), IN
Source
Indian Journal of Science and Technology, Vol 5, No 9 (2012), Pagination: 3263-3267Abstract
A mathematical model will help the engineers in science and technology applications. In this paper, authors studied a temperature-thickness coupling problem of a non-homogeneous rectangular plate in which temperature varies bilinearly&thickness varies linearly in x-direction. Due to non-homogeneity, it is considered that poisson ratio varies exponentially in x direction. Ray-Leigh Ritz method has been adopted to calculate the time period for fixed two modes of vibration for different values of aspect ratio, thermal gradient and taper constants. All results are shown in graphs.Keywords
Vibration, Thermal Gradient, Taper Constant, Aspect Ratio, Time PeriodFull Text
References
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- Effect of Dimethyl Sulphoxides as Permeation Enhancer on Transdermal Patch of Nebivolol Hydrochloride
Authors
1 Department of Pharmaceutics, Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
2 Department of Pharmaceutical Chemistry, Lordshiva College of Pharmacy, Sirsa, Haryana, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 8-11Abstract
A matrix type transdermal patch for delivery of Nebivolol hydrochloride (NEB), is unique as a beta-blocker. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of Nebivolol hydrochloride across rat skin. Films were prepared by using Eudragit RS100 (ERS100) and hydroxy propyl methyl cellulose (HPMC K100M) polymers by incorporating polypropylene glycol (PEG 400) as plasticizer using solvent evaporating method. A total of eight formulations were prepared by using same drug and different polymer ratio and some formulation prepared without (E1-E4)/with (F1-F4) Dimethyl sulphoxides (DMSO) as permeation enhancers in same concentrations. The maximum percent of drug permeation was observed with ERS100 and HPMC K100M (2:8) monolithic system containing 20% Dimethyl sulphoxides (F1). The in vitro release studies revealed that Dimethyl sulphoxides showed better permeation enhancement than without DMSO and the release was sustained up to 48 h and it follows higuchi kinetics. All the films were found to be stable at temperature of 40±2°C and 75±5% relative humidity (RH) as per the international conference on harmonization (ICH) guidelines (Zone IV) for the period of six months with respect to their physical parameters.Keywords
Permeation Enhancer, Polymers, Transdermal Patch, Nebivolol Hydrochloride, Dimethyl Sulphoxides.
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- Synthesis and Evaluating Anti-Inflammatory, Antibacterial Activity of Substituted Benzylidene Thiazolidinediones
Authors
1 Department of Pharmaceutical Chemistry, NIMS University, Shobha Nagar, Delhi Highway, Jaipur-303121 (Rajasthan), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 198-202Abstract
This compound we synthesize by a Knoevenagel condensation of 4-aminobenzaldehyde with compound (I) in presence of sodium acetate, but this compound do not comply with the primary aromatic amine test like nitrous acid test and carbylamine test as well as H1 NMR spectra, in this reaction the amine group of benzaldehyde was further reacted another molecules of aldehydes. We modified the process and synthesized compound (Ia), the nitro group of compound Ia was converted in amino group by reduction.Keywords
Thiazolidinedione, Benzaledhyde, Schiff Base.- Effect of Vibration on Orthotropic Visco-Elastic Rectangular Plate with Two Dimensional Temperature and Thickness Variation
Authors
1 Amity University, Gurgaon - 122413, Haryana, IN
2 Departement of Mathematics, Pacific University, Udaipur – 313024, Rajasthan, IN
Source
Indian Journal of Science and Technology, Vol 9, No 2 (2016), Pagination:Abstract
As a result of the technological developments in civil, mechanical and aeronautical engineering, visco-elastic plate structures gained popularity in the 20th century. The mainstream of visco- elastic materials are receptive to heat in space technology, highly speed space flights, internal combustion engines, satellites, certain parts of mechanical structures have to man oeuvre under elevated temperatures consequently the state of affairs are thermal sensitive. It is observed that thermal effects are recurrently overlooked in most of the cases so far they have to be taken in to concern. In this paper effect of bi-parabolically variation in temperature is premeditated on vibration of an orthotropic rectangular plate and whose thickness also varies bi-parabolically. Frequency equation is derived by using Rayleigh–Ritz technique with a two-term deflection function. Time period, Deflection and Logarithmic decrement at different points for the first two modes of vibration are calculated for various values of thermal gradients, aspect ratio and taper constants. Mathematics Subject Classification: 2014 AMS Classification No. : 70j30
Keywords
Aspect Ratio, Frequency, Thickness, Taper Parameter, Vibration, Visco-ElasticFull Text
- Assessment of Wound Healing Activity of Roots of Bauhinia variegata Linn. by Excision and Incision Model in Albino Rats
Authors
1 Department of Pharmacy, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, IN
2 Department of Pharmacology, KLE’s Colleges of Pharmacy, Rajaji Nagar, Bangaluru, Karnataka, IN
3 Department of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 3 (2015), Pagination: 145-152Abstract
The plant Bauhinia variegata Linn. (Caesalpiniaceae) is commonly known as Mountain Ebony. It is widely used in folklore medicine in treatment of ulcer, to prevent obesity, as an astringent, tonic and in skin diseases. To evaluate the wound healing activity of ethanolic and aqueous extracts of Bauhinia variegata Linn. ischolar_main by excision and incision wound models in rats as there were no scientific reports on its wound healing activity.
Excision and incision wound models were used to evaluate the wound healing activity of both ethanolic and aqueous extracts at 200 and 400 mg/kg b.w. using albino Wistar rats. The wound healing activity was assessed by percentage of wound closure, period of epithelialization, hydroxyproline estimation and histopathological studies of the granulation tissue for excision wound model and incision wound model was evaluated by tensile strength measurement. Treatment with aqueous and ethanolic extracts of ischolar_main of Bauhinia variegata Linn. at both the doses produced significant (P<0.001) wound healing activity. Ethanolic extract produced wound healing activity which was comparable to control in both wound models. The result of wound healing activity was substantiated by the histopathological evaluation. Phenolic content of ethanolic and aqueous extracts were found to be 14.88 and 22.62 μg/mg of pyrocatechol equivalents respectively. The ethanolic and aqueous extracts exhibited significant wound healing activity probably due to the presence of flavonoids.
Keywords
Wound Healing Activity, Bauhinia Variegata Linn, Excision Wound Model, Incision Wound Healing.- Development and Evaluation of Transdermal Drug Delivery System of Ivabradine Hydrochlride
Authors
1 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
2 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 5, No 4 (2013), Pagination: 237-241Abstract
Transdermal patches are designed to slowly deliver the drug substance(s) through the intact skin; resulting in a prolonged and adequately constant systemic absorption rate after passing through the skin barriers, and it avoid first pass effect. Through a diffusion process, the drug enters the bloodstream directly though the skin. For this studies design the transdermal drug delivery system of Ivabradine hydrochloride with ERS100 and Hydroxy propyl methyl cellulose polymer in various concentrations. Propylene glycol was used as a plasticizer and dimethyl sulphoxides used as permeation enhancer. Characterization of transdermal patch is use to check it's quality, thickness, weight of patch, uniformity and in vitro permeation studies. The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future. It was observed that the formulation containing ERS100: HPMC K100M (4:6) showed ideal higuchi release kinetics. On the basis of in vitro drug release through skin permeation performance, Formulation A2 was found to be better than other formulations and it was selected as the optimized formulation. An increasing number of TDD products continue to deliver real therapeutic benefit to patients around the world.Keywords
Ivabradine Hydrochloride, HPMC, ERS100, Transdermal Patch, Permeation Studies.- Formulation and Evaluation of Transdermal Patches of Nebivolol Hydrochloride
Authors
1 Gyan Vihar School of Pharmacy, SGVU, Mahal Road, Jagatpura, Jaipur, IN
2 Lordshiva College of Pharmacy, Sirsa, Haryana, IN
3 Gyan Vihar School of Pharmacy, SGVU, Jaipur, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 272-277Abstract
Aim:- The present study is to formulate the matrix type transdermal patches of Nebivolol hydrochloride as a model drug with combination of HPMC K100M and ERS-100 to minimize the dose of the drug for lesser side effect.
Method:-Matrix type transdermal patches containing Nebivolol hydrochloride were prepared using two polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide was used as penetration enhancer. Major
Results:-The physicochemical parameters like weight variation, thickness, folding endurance, drug content, Percentage moisture absorption and Percentage moisture loss were evaluated. All prepared formulations indicated good physical stability and no skin irritation. In-vitro drug release and drug permeation studies of formulations were performed by using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed best in-vitro skin permeation through rat skin (Wistar albino rat) as compared to all other formulations.
Conclusions:- On the basis of in vitro drug release through skin permeation performance, Formulation F1 was found to be better than other formulations and it was selected as the optimized formulation.
Keywords
Nebivolol Hydrochloride, Transdermal Patch, Polymers, Solvent Evaporation Technique, Skin Permeation.- Vibration of Clamped Non-Homogeneous Square Plate with Non-Uniform Varying Thickness and Thermal Effect
Authors
1 Department of Mathematics, IEC University, Baddi (Solan), H.P., IN